Protein Details: Voltage-gated sodium channel subunit beta-1
Protein ID
ICDB_Pro_0606
Protein Name
Voltage-gated sodium channel subunit beta-1
Gene Name
SCN1B
Organism
Oryctolagus cuniculus (Rabbit)
Length
218 amino acids
AlphaFoldDB
AF-P53788-F1-model_v4.pdb
Function
Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain; heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits; such as SCN1A; SCN2A; SCN3A; SCN4A; SCN5A and SCN10A.
Sequence
MGRLLAFVVGAALVSSAWGGCVEVDSETEAVYGMTFKILCISCKRRSETTAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYQCHVYRLLSFENYEHNTSVVKKIHLEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE
PDB Structures
Ligand Binding
Binding Site
Disease
Location
brain; heart and skeletal muscle
DOI ID
10.1016/0378-1119(95)00871-3
RefSeq
NP_001075828.1